Review articles

- Schulze H, Gaedicke G. Immune thrombocytopenia in children and adults: what's the same, what's different? Haematologica 2011; 96:1739-1741

- Schulze H. Culture of Murine Megakaryocytes and Platelets from Fetal Liver and Bone Marrow. Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives, Methods Mol Biol. 2012;788:193-203

- Schulze H. Gegenwärtige Modelle der Thrombozytopoese. Der Pathologe 2010; Aug 28. [Suppl 2] 31:183–187

- Dame C, Gaedicke G, Schulze H. Physiologie der Megakaryopoese und des Thrombozyten. Monatsschrift Kinderheilkunde 2006; 154: 502-509

- Gaedicke G, Schulze H. Some unsettled Questions in Childhood Thrombocytopenia Caused by Immunologic Platelet Destruction (Acute and Chronic ITP). Pediatric Blood Cancer 2006; 47: 668-670

- Shivdasani RA, Schulze H. Culture, Expansion and Differentiation of Murine Megakaryocytes. Current Protocols in Immunology 2005, Suppl. 67 Chapter 22F.6.1-22F.6.13

- Schulze H, Shivdasani RA. Mechanisms of Thrombopoiesis. Journal of Thrombosis and Hemostasis 2005; 3: 1717-1724

- Schulze H, Shivdasani RA. Molecular Mechanisms of Megakaryocyte Differentiation. Seminars in Thrombosis and Hemostasis 2004; 4: 389-397

- Germeshausen M, Schulze H, Gaudig A, Krukemeier S, Strauss G, Welte K, Ballmaier M. Congenital Amegakaryocytic Thrombocytopenia (CAMT) - a Defect of the Thrombopoietin Receptor c-Mpl. Klin Padiatr. 2001; 213: 155-161

- Strauß G, Ballmaier M, Schulze H, Bogenberger J, Riehm H, Welte K. Significance of Thrombopoietin and its Receptor c-Mpl in Regulation of Thrombocytopoiesis in Thrombocytopenia. Klin. Pädiatr 1996; 208: 168-171

 

TAR-Syndrome and Thrombocytopenia

- Fiedler J, Strauß G, Wannack M, Schwiebert S, Seidel K, Henning K, Klopocki E, Schmugge M, Gaedicke G, Schulze H. Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome, Haematologica. 2011, EPub doi:10.3324/haematol.2011.049619

- Strauß G, Vollert C, von Stackelberg A, Weimann A, Gaedicke G, Schulze H. Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatric Blood Cancer. 2011, 57(4):641-647.

- Jurk K, Schulz AS, Kehrel BE, Räpple D, Schulze H, Möbest D, Friedrich WW, Omran H, Deak E, Henschler R, Scheele JS, Zieger B. Reconstitution of integrin-dependent platelet and leukocyte function in siblings with Leukocyte Adhesion Deficiency-1/variant (LAD1v, LAD-III) after allogeneic stem cell transplantation. Thromb. Haemost. 2010, 103(5): 1053-1064.

- Klopocki E*, Schulze H*, Strauß G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers H, Ullmann R, Horn D, Mundlos S. Complex inheritance pattern resembling autosomale-recessive inheritance involving a microdeletion in chromosome in thrombocytopenia-absent radius (TAR) syndrome Am. J. Human Genet. 2007, 80: 232-240 (*Co-first-authors)

- Ballmaier M, Germeshausen M, Schulze H, Cherkaoui K, Lang S, Gaudig A, Krukemeier S, Eilers M, Strauss G, Welte K. c-mpl Mutations are the Cause of Congenital Amegakaryocytic Thrombocytopenia. Blood 2001; 97: 139-146

- Cremer M, Schulze H, Linthorst G, Folman CC, Wehnert S, Strauß G, von dem Borne AEGK, Welte K, Ballmaier M. Serum Levels of Thrombopoietin, IL-11 and IL-6 in Pediatric Thrombocytopenias. Ann Hematol 1999; 78: 401-407

- Ballmaier M, Schulze H, Cremer M, Folman C, Strauß G, Welte K. Defective c-Mpl Signaling in the Syndrome of Thrombocytopenia with Absent Radii. Stem Cells 1998; 16(suppl. 2): 177-184

- Ballmaier M*, Schulze H*, Strauß G, Cherkaoui K, Wittner N, Lynen S, Wolters S, Bogenberger J, Welte K. Thrombopoietin in Patients with Congenital Thrombocytopenia and Absent Radii: Elevated Serum Levels, Normal Receptor Expression, But Defective Reactivity to Thrombopoietin. Blood 1997; 90: 612-619 (*Co-first-authors)

 

Platelets and Megakaryocytes

- Winter O, Moser K, Mohr E, Zotos D, Kaminski H, Szyska M, Roth K, Wong DM, Dame C, Tarlinton D, Schulze H, MacLennan I, Manz RA. Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. Blood 2010; 116: 1867-1875

- Lütteke N, Raftery MJ, Lalwani P, Lee MH, Giese T, Voigt S, Bannert N, Schulze H, Krüger DH, Schönrich G. Switch to high-level virus replication and HLA class I upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. Virology 2010; 405 (1): 70-80.

- Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood 2009;114: 5532-5540

- Schulze H, Dose M, Korpal M, Meyer I, Italiano JE Jr., Shivdasani RA. RanBP10 is a cytoplasmic guanine nucleotide-exchange factor that modulates non-centrosomal microtubules. Journal of Biological Chemistry 2008; 283 (20): 14109-14119.

- Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE, Jr. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood 2008;111: 4605-4616.

- Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE Jr, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science 2007; 317: 1767-1770.

- Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke, P, Schropp P, Mühlstedt S, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest 2007; 117: 3540-3550.

- Schulze H, Korpal M, Hurov J, Kim SW, Zhang, J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006; 107: 3868-3875.

- Patel SR, Richardson J, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE Jr. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood 2005, 106, 4076-4085.

- Schulze H, Korpal M, Bergmeier W, Italiano JE Jr, Wahl SM, Shivdasani, RA. Interactions between the megakaryocyte/platelet-specific beta1-tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet function. Blood 2004; 104: 3949-3957

- Schulze H, Ballmaier M, Welte K, Germeshausen M. Thrombopoietin Induces the Generation of Distinct Stat1, Stat3, Stat5a and Stat5b Homo- and Heterodimeric Complexes With Different Kinetics In Human Blood Platelets. Exp Hematol 2000; 28: 294-304

- Eilers M, Schulze H, Welte K, Ballmaier M. Thrombopoietin acts Synergistically on Ca2+ Mobilization in Platelets Caused by ADP or Thrombin Receptor Agonist Peptide. Biochem Biophys Res Commun 1999; 263: 230-238

 

Miscellaneous

- Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, DeFrances J, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes and Development, 2007; 21(1): 98-111.

- Germeshausen M, Schulze H, Kratz C, Wilkens L, Repp R, Shannon K, Welte K, Ballmaier M. An acquried G-CSF receptor gene mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia. Leukemia, 2005; 19(4): 611-617

- Germeshausen M, Ballmaier M, Schulze H, Welte K, Flohr T, Beiske K, Storm-Mathisen I, Abrahamsen T. Granulocyte Colony-Stimulating Factor Receptor Mutations in a Patient with Acute Lymphoblastic Leukemia Secondary to Severe Congenital Neutropenia. Blood 2001; 97: 829-830

- Germeshausen M, Schulze H, Ballmaier M, Zeidler C, Welte K. Mutations in the Gene Encoding Neutrophil Elastase (ELA2) are not Sufficient to Cause the Phenotype of Congenital Neutropenia. Br J Haematol. 2001; 115: 222-224