Selected Publications
Current publications (2019-)
2024
- Mueller KAL, Langnau C, Harm T, Sigle M, Mott K, Droppa M, Borst O, Rohlfing A, Gekeler S, Günter M, Goebel N, Franke UFW, Radwan M, Schlensak C, Janning H, Scheuermann S, Seitz CM, Rath D, Kreisselmeier K-M. Castor T, Mueller II, Schulze H, Autenrieth SE, Gawaz MP. Macrophage migration inhibitory 1 factor promotes thrombo-inflammation and predicts fast progression of aortic stenosis. ATVB 2024, manuscript accepted for publication.
- Herrmann J*, Weiss LJ*, Just B, Mott K, Drayss M, Kleiss J, Riesner J, Notz Q, Röder D, Leyh R, Beck S, Weismann D, Nieswandt B, Lotz C, Meybohm P§, Schulze H§. ECMO aggravates platelet GPV shedding and δ-granule deficiency in COVID-19-associated acute respiratory distress syndrome. JTH 2024. May 17:S1538-7836(24)00290-3. doi: 10.1016/j.jtha.2024.05.008. (* shared first-authors, § shared last-authors)
2023
- Ross JE, Mohan S, Zhang J, Sullivan MJ, Bury L, Lee K, Futchi I, Frantz A, McDougal D, Perez Botero J, Cattaneo M, Cooper N, Downes K, Gresele P, Keenan C, Lee A, Megy K, Morange P, Morgan NV, Schulze H, Zimowski K, Freson K*, Lambert M. Evaluating the clinical validity of genes related to hemostasis and thrombosis using the ClinGen gene curation framework. JTH 2023 Nov 26:S1538-7836(23)00849-8. DOI: 10.1016/j.jtha.2023.11.011
- Ballmaier M, Germeshausen M, Schulze H, Andres O. THROMKIDplus Patient Registry and Biomaterial Banking for Children with Inherited Platelet Disorders. Hämostaseologie, 2023. Nov 2. doi: 10.1055/a-2117-4639. Online ahead of print.
- de Jonckheere B, Kollotzek F, Münzer P, Göb V, Fischer M, Mott K, Coman C, Troppmair NN, Manke M, Zdanyte M, Harm T, Sigle M, Kopczynski D, Bileck A, Gerner C, Hoffmann N, Heinzmann D, Assinger A, Gawaz M, Stegner D, Schulze H, Borst O, Ahrends A. Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation. Nat Cardiovasc Res 2023, 2, 835–852. doi.org/10.1038/s44161-023-00325-8.
- Elgheznawy A, Öftering P, Englert M, Mott K, Kaiser F, Kusch C, Gbureck U, Bösl MR, Schulze H, Nieswandt B, Vögtle T*, Hermanns HM*. Loss of zinc transporters ZIP1 and ZIP3 augments platelet reactivity in response to thrombin and accelerates thrombus formation in vivo. Frontiers. 2023, Jun 8;14:1197894. doi: 10.3389/fimmu.2023.1197894. eCollection 2023
- Gebetsberger J*, Mott K*, Bernar A, Klopocki E, Streif W, Schulze H. State-of-the-art targeted high-throughput sequencing for detecting inherited platelet disorders. Hämostaseologie 2023, Aug;43(4):244-251. doi: 10.1055/a-2099-3266. Epub 2023 Aug 23.
- Mott K, Schulze H. Isolation, in vitro differentiation and culture of murine megakaryocytes from fetal liver and adult bone marrow. Curr Protoc. 2023 May;3(5):e783. doi: 10.1002/cpz1.783.
- Strauss G, Mott K, Klopocki E, Schulze H. Thrombocytopenia Absent Radius (TAR)-Syndrome: From current genetics to patient self-empowerment. Hämostaseologie 2023, Aug;43(4):252-260. doi: 10.1055/a-2088-1801. Epub 2023 Aug 23.
- Weiss LJ, Drayss M, Mott K, Beck S, Unsin D, Just B, Speer CP, Härtel C, Andres O*, Schulze H*. Ontogenesis of functional platelet subpopulations from preterm and term neonates to adulthood: The PLINIUS study. Blood Adv. 2023; Apr 12:bloodadvances.2023009824. doi: 10.1182/bloodadvances.2023009824. ; * equal distribution
- Manke MC, Rolsan A, Walker B, Münzer P, Kollotzek F, Peng B, Mencl S, Coman C, Steubing R, Schulze H, Lieberman AP, Lang F, Gawaz M, Kleinschnitz C, Lukowski R, Ahrends R, Bobe R, Borst O. Niemann-Pick C1 protein regulates platelet membrane-associated Ca2+ signalling in thrombo-occlusive diseases in mice. J. Thr. Haemost. 2023, manuscript accepted for publication.
- Spindler M*, Mott K*, Schulze H, Bender M. Rapid isolation of mature murine primary megakaryocytes by size exclusion via filtration. Platelets. 2023, manuscript accepted for publication.
- Dirks J, Andres O, Paul L, Manukjan G, Schulze H, Morbach H. IgD shapes the pre-immune naïve B cell compartment in humans. Front. Immunol. - B Cell Biology, 2023, Jan 26;14:1096019. doi: 10.3389/fimmu.2023.1096019.
- Weiss LJ*, Drayss M*, Mott K, Droste M, Just B, Arold AM, Nieswandt B, Weismann D, Stegner D, Schulze H. The homophilic CD84 receptor is upregulated on platelets in COVID-19 and sepsis. Thrombosis Research. 2022 Dec;220:121-124. doi: 10.1016
- Weiss LJ, Drayss M, Manukjan G, Zeitlhöfler M, Kleiss J, Weigel M, Herrmann J, Mott K, Beck S, Burkard P, Lâm TT, Althaus K, Bakchoul T, Frantz S, Meybohm P, Nieswandt B, Weismann D*, Schulze H*. Uncoupling of platelet granule release and integrin activation suggests GPIIb/IIIa as therapeutic target in COVID-19. Blood Adv. 2022. Sep 2:bloodadvances.2022008666. doi: 10.1182/bloodadvances.2022008666.
- Englert M, Aurbach K, Becker IC, Gerber A, Heib T, Wackerbarth LM, Kusch C, Mott K, Araujo GHM, Baig AA, Dütting S, Knaus UG, Stigloher C, Schulze H, Nieswandt B, Pleines I, Nagy Z. Impaired microtubule dynamics contribute to microthrombocytopenia in RhoB-deficient mice. Blood Adv. 2022; Sep 13;6(17):5184-5197.
- Becker IC*, Nagy, Z*, Manukjan G, Haffner-Luntzer, Englert M, Heib T, Vögtle T, Gross C, Bharti R, Dietrich S, Mott K, Heck J, Stegmaier S, Jeschke A, Schinke T, Schlegel N, Heckel T, Stegner D, Pleines I, Ignatius A, Schulze H*, Nieswandt B*. G6b-B regulates an essential step in megakaryocyte maturation. Blood Adv. 2022; 6(10):3155-3161.
- Rosa A, Butt E, Hopper CP, Loroch S, Bender M, Schulze H, Sickmann A, Vorlova S, Seizer P, Heinzmann, Zernecke A. Cyclophilin A is not acetylated at Lysine-82 and Lysine-125 in resting and stimulated platelets. Int J Mol Sci., 2022; 23(3):1469
- Laukner A, Truchet L, Manukjan G, Schulze H, Langbein-Detsch I, Müller E, Leeb T, Kehl A. Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs. Genes 2021; 12(7):1092. doi: 10.3390/genes12071092.
- Megy K, Downes K, Morel-Kopp M-C, Bastida JM, Brooks S, Bury L, Leinoe E, Gomez K, Morgan NV, Othman M, Ouwehand WH, Perez Botero J, Rivera J, Schulze H, Trégouët D-A, Freson K. GoldVariants, a resource for sharing rare genetic variants detected in bleeding, thrombotic and platelet disorders: Communication from the ISTH SSC Subcommittee on Genomics in Thrombosis and Hemostasis. J Thromb Haemost. 2021; 19(10):2612-2617.
- Herrmann J, Notz Q, Schlesinger T, Stumpner J, Kredel M, Sitter M, Schmid B, Kranke P, Schulze H, Meybohm P, Lotz C. Point of care diagnostic of hypercoagulability and platelet function in COVID-19 induced acute respiratory distress syndrome: a retrospective observational study. Thrombosis Journal 2021; 19:39. doi.org/10.1186/s12959-021-00293-8
- Heib T, Herrmans J, Manukjan G, Englert M, Kusch C, Becker IC, Gerber A, Wackerbarth LM, Burkhard P, Dandekar T, Balkenhol J, Jahn D, Beck S, Meub M, Dütting S, Stigloher C, Sauer M, Cherpokova D, Schulze H, Brakebusch C, Nieswandt B, Nagy Z, and Pleines I. RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes. Cell Reports, 2021; 35(6):109102. doi: 10.1016/j.celrep.2021.109102.
- Weiss LJ, Manukjan G, Pflug A, Winter N, Weigel M, Nagler N, Kredel M, Lam T-T, Nieswandt B, Weismann D, Schulze H. Acquired platelet GPVI receptor dysfunction in critically-ill patients with sepsis. Blood 2021; 137(22):3105-15.
- Wagner N*, Mott K*, Upcin B, Stegner D, Schulze H*, Ergün S. CXCL12-abundant reticular (CAR) cells direct megakaryocyte protrusions across the bone marrow sinusoid wall. Cells 2021, 10, 722. doi.org/10.3390/cells10040722
- Althaus K, Marini I, Zlamal J, Pelzl L, Singh A, Häberle H, Mehrländer M, Hammer S, Schulze H, Bitzer M, Malek N, Rath D, Bösmüller H, Nieswandt B, Gawaz M, Bakchoul T, Rosenberger T. Severe COVID-19 infection is associated with increased antibody-mediated platelet apoptosis, Blood 2021;137(8):1061-1071. doi: 10.1182/blood.2020008762.
- Cullmann K, Jahn M, Spindler M, Schenk F, Manukjan G, Mucci A, Steinemann D, Boller K, Schulze H, Bender M, Moritz T, Modlich U. Generation of megakaryocytes from murine induced pluripotent stem cells by the inducible overexpression of supporting factors. rpth 2021;5:111–124.
- Becker IC, Scheller I, Wackerbarth LM, Beck S, Heib T, Aurbach K, Manukjan G, Gross C, Spindler M, Nagy Z, Witke W, Lappalainen P, Bender M, Schulze H, Pleines I, Nieswandt B. Actin/microtubule crosstalk during platelet biogenesis in mice is critically regulated by Twinfilin1 and Cofilin1. Blood Adv. 2020 May 26;4(10):2124-2134.
- Rommel M, Milde C, Eberle R, Schulze H, Modlich U. Endothelial-platelet interactions in influenza-induced pneumonia: a potential therapeutic target? Anatomia, Histologia, Embryologia 2020 Sep;49(5):606-619. doi: 10.1111/ahe.12521.
- Manukjan G, Wiegering V, Reindl T, Strauß G, Klopocki E, Schulze H*, Andres O*. Novel variants in FERMT3 and RASGRP2 in consideration of genetic linkage in Glanzmann-like bleeding disorders. Pediatric Blood Cancer 2020 Feb;67(2):e28078. doi: 10.1002/pbc.28078. (corresponding author)
- Vögtle T, Sharma S, Mori J, Nagy Z, Semeniak D, Scandola C, Geer MJ, Smith CW, Lane J, Pollack S, Lassila R, Jouppila A, Barr AJ, Ogg DJ, Howard TD, McMiken HJ, Warwicker J, Geh C, Rowlinson R, Abbott WM, Eckly A, Schulze H, Wright GJ, Mazharian A, Fütterer K, Rajesh S, Douglas MR, Senis YA. Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. eLife 2019, Aug 22;8. pii: e46840. doi: 10.7554/eLife.46840.
- Geue S, Aurbach K, Manke M-C, Manukjan G, Münzer P, Stegner D, Brähler C, Walker-Allgaier B, Märlin M, Borst C, Quintanilla-Martinez L, Rath D, Geisler T, Salih H, Seizer P, Lang F, Nieswandt B, Gawaz M, Schulze H, Pleines I, Borst O. Pivotal Role of PDK1 in Megakaryocyte Cytoskeletal Dynamics and Polarization during Platelet Biogenesis. Blood. 2019, 134(21):1847-1858. doi:10.1182/blood.2019000185.
- Semeniak D, Faber K, Öftering P, Manukjan G, Schulze H. Impact of Itga2-Gp6-double collagen receptor deficient mice for bone marrow megakaryocytes and platelets. PLoS One. 2019, Aug 9;14(8):e0216839. doi: 10.1371/journal.pone.0216839. eCollection.
- Eyrich M, Schulze H. HLA matching in pediatric stem cell transplantation. Transfusion Medicine and Hemotherapy. 2019, 46:348-354. (DOI:10.1159/000502422).
- Gotru SK, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM, Braun A. Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Scientific Reports. 2019, 9(1):8333. doi: 10.1038/s41598-019-44751-w.
- Schuhmann MK, Kraft P, Bieber M, Kollikowski AM, Schulze H, Nieswandt B, Pham M, Stegner D, Stoll G. Targeting platelet GPVI plus rt-PA administration but not α2β1-mediated collagen binding protects against ischemic brain damage in mice. Int J Mol Sci. 2019, 20(8). pii: E2019. doi: 10.3390/ijms20082019
- Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H. Functional classification of pediatric patients with non-syndromic delta-storage pool deficiency. Hämostaseologie, 2019, 39(4):383-391. doi: 10.1055/s-0038-1675574.
Review articles
- Schulze H and Stegner D. Imaging of Platelet Production In Vivo. Res Pract Thromb Haemost, 2018, manuscript accepted for publication. Res Pract Thromb Haemost, 2018 Jun 10;2(3):461-468.- Schulze H. Culture, Expansion, and Differentiation of Murine Megakaryocytes from Fetal Liver, Bone Marrow and Spleen. Current Protocols in Immunology; 2016 Feb 2;112:22F.6.1-22F.6.15
- Andres O, Schulze H*, Speer C*. Platelets in Neonatal Infants: Distinct Central Mediators in Haemostasis, Antimicrobial Defence and Inflammation. (* joint authorship) Thrombosis and Haemostasis 2015; Jan;113(1):3-12. doi: 10.1160/TH14-05-0476.
- Schulze H. Gegenwärtige Modelle der Thrombozytopoese. Der Pathologe 2010; [Suppl 2] 31:183–187
- Dame C, Gaedicke G, Schulze H. Physiologie der Megakaryopoese und des Thrombozyten. Monatsschrift Kinderheilkunde 2006; 154: 502-509
- Gaedicke G, Schulze H. Some unsettled Questions in Childhood Thrombocytopenia Caused by Immunologic Platelet Destruction (Acute and Chronic ITP). Pediatric Blood Cancer 2006; 47: 668-670
- Shivdasani RA, Schulze H. Culture, Expansion and Differentiation of Murine Megakaryocytes. Current Protocols in Immunology 2005, Suppl. 67 Chapter 22F.6.1-22F.6.13
- Schulze H, Shivdasani RA. Mechanisms of Thrombopoiesis. Journal of Thrombosis and Hemostasis 2005; 3: 1717-1724
- Schulze H, Shivdasani RA. Molecular Mechanisms of Megakaryocyte Differentiation. Seminars in Thrombosis and Hemostasis 2004; 4: 389-397
- Germeshausen M, Schulze H, Gaudig A, Krukemeier S, Strauss G, Welte K, Ballmaier M. Congenital Amegakaryocytic Thrombocytopenia (CAMT) - a Defect of the Thrombopoietin Receptor c-Mpl. Klin Padiatr. 2001; 213: 155-161
- Strauß G, Ballmaier M, Schulze H, Bogenberger J, Riehm H, Welte K. Significance of Thrombopoietin and its Receptor c-Mpl in Regulation of Thrombocytopoiesis in Thrombocytopenia. Klin. Pädiatr 1996; 208: 168-171
Thrombocytopenia, Thrombocytopathy and TAR Syndrome
- Andres O, König EM, Althaus K. Bakchoul T, Bugert P, Eber S, Knöfler R, Kunstmann E, Manukjan G, Meyer O, Strauß G, Streif W, Thiele T, Wiegering V, Klopocki E, Schulze H. Use of targeted high-throughput sequencing for genetic classification of patients with bleeding diathesis and suspected platelet disorder. TH Open, 2018, Dec 30;2(4):e445-e454. doi: 10.1055/s-0038-1676813. eCollection 2018 Oct.- Manukjan G, Eilenberger J, Andres O, Schambeck C, Eber S, Schulze H. Functional classification of pediatric patients with non-syndromic delta-storage pool deficiency. Hämostaseologie, 2018, Nov 21. doi: 10.1055/s-0038-1675574.
- Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. Diagnosis of platelet function disorders: A standardised, rational and modular flow cytometric approach. Platelets, 2018; 29(4):347-356.
- Manukjan G, Bösing H, Schmugge M, Strauß G, Schulze H. Impact of Genetic Variants on Haematopoiesis in Patients with Thrombocytopenia Absent Radii (TAR) Syndrome. British Journal of Haematology, 2017, 179(4):606-617.
- Schulze H*, Schlagenhauf A*, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König E-M, Haidl H, Panzer S, Althaus K, Muntean W, Schwinger W, Urban C, Greinacher A, Bakchoul T*, Seidel MG*. (*joint authorship) Recessive Grey Platelet-like Syndrome with Unaffected Erythropoiesis in the Absence of the Splice Isoform GFI1B-p37. Haematologica, 2017, Sep;102(9):e375-e378.
- Andres O, Wiegering W, König E-M, Schneider AL, Semeniak D, Stritt S, Klopocki E, Schulze H. A novel two-nucleotide deletion in HPS6 affects mepacrine uptake and platelet dense granule secretion in a family with Hermansky-Pudlak syndrome, Pediatric Blood Cancer, 2016; 64(5). doi: 10.1002/pbc.26320
- Crazzolara R, Maurer K, Schulze H, Zieger B, Zustin J, Schulz AS. A new mutation in the KINDLIN-3 gene ablates integrin-dependent leukocyte, platelet and osteoclast function in a patient with leukocyte adhesion deficiency-III. Pediatr Blood Cancer. 2015 Sep;62(9):1677-9. doi: 10.1002/pbc.25537
- Westbury SK, Turro E, Greene D, Lentaigne C, Kelly AM, Bariana TK, Simeoni I, Pillois X, Atwood A, Austin S, Jansen SBG, Bakchoul T, Crisp-Hihn A, Erber WN, Favier R, Foad N, Gattens M, Jolley JD, Liesner R, Meacham S, Millar CM, Nurden AT, Peerlinck K, Perry DJ, Poudel P, Schulman S, Schulze H, Stephens JC, Furie B, Robinson PN, van Geet C, Rendon A, Gomez K, Laffan MP, Nurden P, Ouwehand WH, Richardson S, Mumford AD, Freson K on behalf of the BRIDGE-BPD consortium. Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders. Genome Medicine 2015 Apr 9;7(1):36. doi: 10.1186/s13073-015-0151-5
- Streif W, Knöfler R, Eberl W, Andres O, Bakchoul T, Bergmann F, Beutel K, Dittmer R, Gehrisch S, Gottstein S, Halimeh S, Haselböck J, Hassenpflug WA, Heine S, Holzhauer S, King S, Kirchmaier CM, Krause M, Kreuz W, Lösche W, Mahnel R, Maurer M, Nimtz-Talaska A, Olivieri M, Rott H, Schambeck ChM, Schedel A, Schilling FH, Schmugge M, Schneppenheim R, Scholz U, Scholz T, Schulze H, Siegemund A, Strauß G, Sykora KW, Wermes C, Wiegering V, Wieland I, Zieger B, Zotz RB. Therapy of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.)] Hamostaseologie. 2014;34(4):269-75.
- Knöfler R*, Eberl W*, Schulze H*, Bakchoul T, Bergmann F, Gehrisch S, Geisen C, Gottstein S, Halimeh S, Harbrecht U, Kappert G, Kirchmaier C, Kehrel B, Lösche W, Krause M, Mahnel R, Meyer O, Pilgrimm AK, Pillitteri D, Rott H, Santoso S, Siegemund A, Schambeck C, Scheer M, Schmugge M, Scholl T, Strauß G, Zieger B, Zotz R, Herrmann M, Streif W. (*joint authorship) Diagnosis of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e.V.) Hämostaseologie. 2014 5;34(3):201-12 AWMF-Register Nr. 086-003. www.awmf.org/leitlinien/detail/ll/086-003.html
-Albers C*, Paul D*, Schulze H*, Freson K, Stephens J, Cvejic A, Kostadima M, Bertone P, Breuning M, Debili N, Deloukas P, Favier R, Fiedler J, Hobbs C, Huang N, Hurles M, Jolley J, Krapels I, Nurden P, Ruivenkamp C, Sambrook J, Smethurst P, Strauß G, van Geet C, Newbury-Ecob R**, Ouwehand W**, Ghevaert C**. Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome. (*, ** joint authorship). Nature Genetics 2012. 44(4):435-9, S1-2.
- Fiedler J, Strauß G, Wannack M, Schwiebert S, Seidel K, Henning K, Klopocki E, Schmugge M, Gaedicke G, Schulze H. Two patterns of thrombopoietin signaling suggest no coupling between platelet production and thrombopoietin reactivity in thrombocytopenia-absent radii syndrome, Haematologica. 2012 Jan;97(1):73-81.
- Schulze H, Gaedicke G. Immune thrombocytopenia in children and adults: what's the same, what's different? Haematologica 2011; 96:1739-1741
- Strauß G, Vollert C, von Stackelberg A, Weimann A, Gaedicke G, Schulze H. Immature platelet count: a simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatric Blood Cancer. 2011, 57(4):641-647.
- Jurk K, Schulz AS, Kehrel BE, Räpple D, Schulze H, Möbest D, Friedrich WW, Omran H, Deak E, Henschler R, Scheele JS, Zieger B. Novel integrin-dependent platelet malfunction in siblings with leukocyte adhesion deficiency-III (LAD-III) caused by a point mutation in FERMT3. Thromb. Haemost. 2010, 103(5): 1053-1064.
- Klopocki E*, Schulze H*, Strauß G, Ott CE, Hall J, Trotier F, Fleischhauer S, Greenhalgh L, Newbury-Ecob RA, Neumann LM, Habenicht R, König R, Seemanova E, Megarbane A, Ropers H, Ullmann R, Horn D, Mundlos S. Complex inheritance pattern resembling autosomale-recessive inheritance involving a microdeletion in thrombocytopenia-absent radius (TAR) syndrome Am. J. Human Genet. 2007, 80: 232-240 (*Co-first-authors)
- Ballmaier M, Germeshausen M, Schulze H, Cherkaoui K, Lang S, Gaudig A, Krukemeier S, Eilers M, Strauss G, Welte K. c-mpl Mutations are the Cause of Congenital Amegakaryocytic Thrombocytopenia. Blood 2001; 97: 139-146
- Cremer M, Schulze H, Linthorst G, Folman CC, Wehnert S, Strauß G, von dem Borne AEGK, Welte K, Ballmaier M. Serum Levels of Thrombopoietin, IL-11 and IL-6 in Pediatric Thrombocytopenias. Ann Hematol 1999; 78: 401-407
- Ballmaier M, Schulze H, Cremer M, Folman C, Strauß G, Welte K. Defective c-Mpl Signaling in the Syndrome of Thrombocytopenia with Absent Radii. Stem Cells 1998; 16(suppl. 2): 177-184
- Ballmaier M*, Schulze H*, Strauß G, Cherkaoui K, Wittner N, Lynen S, Wolters S, Bogenberger J, Welte K. Thrombopoietin in Patients with Congenital Thrombocytopenia and Absent Radii: Elevated Serum Levels, Normal Receptor Expression, But Defective Reactivity to Thrombopoietin. Blood 1997; 90: 612-619 (*Co-first-authors)
Platelets, Megakaryocytes and Stem cells
- Mekala SR, Wörsdörfer P, Bauer J, Stoll O, Wagner N, Reeh L, Loew K, Eckner G, Kwok CK, Wischmeyer E, Dickinson ME, Schulze H, Stegner D, Benndorf RA, Edenhofer F, Pfeiffer V, Kuerten S, Frantz S, Ergün S. Generation of Cardiomyocytes from Vascular Adventitia-Resident Stem Cells. Circ. Res, 2018, 123:686-699.
- Stritt S, Birkholz I, Beck S, Sorrentino S, Sapra TK, Viaud J, Heck J, Gaits-Iacovoni F, Schulze H, Du X, Hartwig JH, Braun A, Bender M, Medalia O, and Nieswandt B. Profilin 1-mediated cytoskeletal rearrangements regulate integrin function in mouse platelets. Blood Advances, 2018; 2(9):1040-1045.
- Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez-Menendez I, Märklin M, Quintanilla-Martinez L, Salih H, Lichtfield DW, Buchou T, Kleinschnitz C, Lang F, Nieswandt B, Pleines I, Schulze H, Gawaz M, Borst O. CK2β critically regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis in vivo. Blood, 2017; 130(25):2774-2785.
- Stegner D, van Eeuwijk JMM, Angay O, Gorelashvili M, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, and Heinze K. Thrombopoiesis is spatially regulated by the bone marrow vasculature. Nature Communications, 2017, 8(1):127.
- Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig A, Gorelashvili M, Gerner F, Heinze K, Ware J, Krohne G, Ruggeri Z, Nurden A, Schulze H, Modlich U, Pleines I, Brakebusch, Nieswandt B. A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis. Nature Communications, 2017, 8:15838. doi: 10.1038/ncomms15838.
- Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H. Proplatelet formation is selectively inhibited by collagen type I via Syk-independent GPVI signaling, Journal of Cell Science, 2016;129(18):3473-84.
- Stritt S, Nurden P, Favier R, Ferioli S, Gortu SK, von Eeuwijk JMM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, NIHR BioResource, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture. Nature Communications 2016;7:11097. doi: 10.1038/ncomms11097.
- Bender M*, Stritt S*, Nurden P, van Eeuwijk J, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze K, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nature Communications 2014,Sep 4;5:4746. doi: 10.1038/ncomms5746
- Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood, 2013, 122: 3178-3187.
- Lachmann N*, Todorova K*, Schulze H**, Schönemann C**. Luminex and its Applications for Solid Organ Transplantation, Hematopoietic Stem Cell Transplantation and Transfusion. (*, ** joint authorship) Transfusion Medicine and Hemotherapy 2013;40:182-189.
- Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE Jr., Hartwig JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp. Hematology 2013, 41(1):91-101.e4.
- Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE Jr, Dütting S, Nieswandt B, Bachmann S, Schulze H. Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Blood 2012;120: 3594-3602.
- Schulze H. Culture of Murine Megakaryocytes and Platelets from Fetal Liver and Bone Marrow. Platelets and Megakaryocytes: Volume 3, Additional Protocols and Perspectives, Methods Mol Biol. 2012;788:193-203.
- Winter O, Moser K, Mohr E, Zotos D, Kaminski H, Szyska M, Roth K, Wong DM, Dame C, Tarlinton D, Schulze H, MacLennan I, Manz RA. Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow. Blood 2010; 116: 1867-1875
- Lütteke N, Raftery MJ, Lalwani P, Lee MH, Giese T, Voigt S, Bannert N, Schulze H, Krüger DH, Schönrich G. Switch to high-level virus replication and HLA class I upregulation in differentiating megakaryocytic cells after infection with pathogenic hantavirus. Virology 2010; 405 (1): 70-80.
- Kunert S, Meyer I, Fleischhauer S, Wannack M, Fiedler J, Shivdasani RA, Schulze H. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood 2009;114: 5532-5540
- Schulze H, Dose M, Korpal M, Meyer I, Italiano JE Jr., Shivdasani RA. RanBP10 is a cytoplasmic guanine nucleotide-exchange factor that modulates non-centrosomal microtubules. Journal of Biological Chemistry 2008; 283 (20): 14109-14119.
- Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE, Jr. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood 2008;111: 4605-4616.
- Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE Jr, Shivdasani RA, von Andrian UH. Dynamic visualization of thrombopoiesis within bone marrow. Science 2007; 317: 1767-1770.
- Grosse J, Braun A, Varga-Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, Hanke, P, Schropp P, Mühlstedt S, Schmittwolf C, Jagla W, Yu P, Kerkau T, Schulze H, Nehls M, Nieswandt B. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest 2007; 117: 3540-3550.
- Schulze H, Korpal M, Hurov J, Kim SW, Zhang, J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Blood 2006; 107: 3868-3875.
- Patel SR, Richardson J, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE Jr. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood 2005, 106, 4076-4085.
- Schulze H, Korpal M, Bergmeier W, Italiano JE Jr, Wahl SM, Shivdasani, RA. Interactions between the megakaryocyte/platelet-specific beta1-tubulin and the secretory leukocyte protease inhibitor SLPI suggest a role for regulated proteolysis in platelet function. Blood 2004; 104: 3949-3957
- Schulze H, Ballmaier M, Welte K, Germeshausen M. Thrombopoietin Induces the Generation of Distinct Stat1, Stat3, Stat5a and Stat5b Homo- and Heterodimeric Complexes With Different Kinetics In Human Blood Platelets. Exp Hematol 2000; 28: 294-304
- Eilers M, Schulze H, Welte K, Ballmaier M. Thrombopoietin acts Synergistically on Ca2+ Mobilization in Platelets Caused by ADP or Thrombin Receptor Agonist Peptide. Biochem Biophys Res Commun 1999; 263: 230-238
Miscellaneous
- Kunz M, Wolf B, Schulze H, Atlan D, Walles T, Walles H, Dandekar T. Non-coding RNAs in lung cancer: Contribution of bioinformatics analysis to the development of non-invasive diagnostic tools, Genes, 2016, 26;8(1). pii: E8. doi: 10.3390/genes8010008.
- Lachmann N*, Todorova K*, Schulze H**, Schönemann C**. Systematic comparison of four cell- and Luminex-based methods for assessment of complement-activating antibodies. (*, ** joint authorship) Transplantation 2013, 15;95(5):694-700.
- Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, DeFrances J, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes and Development, 2007; 21(1): 98-111.
- Germeshausen M, Schulze H, Kratz C, Wilkens L, Repp R, Shannon K, Welte K, Ballmaier M. An acquried G-CSF receptor gene mutation results in increased proliferation of CMML cells from a patient with severe congenital neutropenia. Leukemia, 2005; 19(4): 611-617
- Germeshausen M, Ballmaier M, Schulze H, Welte K, Flohr T, Beiske K, Storm-Mathisen I, Abrahamsen T. Granulocyte Colony-Stimulating Factor Receptor Mutations in a Patient with Acute Lymphoblastic Leukemia Secondary to Severe Congenital Neutropenia. Blood 2001; 97: 829-830
- Germeshausen M, Schulze H, Ballmaier M, Zeidler C, Welte K. Mutations in the Gene Encoding Neutrophil Elastase (ELA2) are not Sufficient to Cause the Phenotype of Congenital Neutropenia. Br J Haematol. 2001; 115: 222-224